Severe malaria in holoendemic regions primarily manifests as severe malaria anemia [SMA, hemoglobin (Hb) < 5.0 g/dl] in children less than 5 years of age who are yet to develop naturally-acquired immunity to malaria (Ong’echa et al., 2006; Obonyo et al., 2007). This evidence concerns the gene GSTM1 and malaria.