Furthermore, we concluded that SLAMF1, TCF7, TNFRSF25, MNT, and VEGFA were protective factors, whereas GRWD1, SLC6A3, GMIP, and LAG3 appeared to be harmful factors in CLL, based on the aforementioned hazard ratios of univariate and multivariate regression analyses. The gene discussed is TNFRSF25; the disease is B-cell chronic lymphocytic leukemia.