In the present study, SLAMF1, TCF7, TNFRSF25, MNT, and VEGFA were protective factors, whereas GRWD1, SLC6A3, GMIP, and LAG3 appeared to be harmful factors in CLL; we subsequently discussed each gene in the prognostic model. This evidence concerns the gene TNFRSF25 and B-cell chronic lymphocytic leukemia.