The loss of LNCPINT-derived circRNAs in the NAFLD group lead to an increased level and functional activation of these miRNAs, and subsequent downregulation of AMPK-α1 expression at the transcriptional and translational levels (Figures 6C,F,G) in hepatocytes (Figure 6J). This evidence concerns the gene PRKAA1 and metabolic dysfunction-associated steatotic liver disease.