Palmitate exposure and metabolic oxidative stress have been shown to activate the expression of miR-466 and the miR-297-669 cluster (Li et al., 2011a; Druz et al., 2012), which further regulates NAFLD through peroxisome proliferator-activated receptor-gamma coactivator 1-α (PPARGC1A) (Mukushkina et al., 2020; Taghvaei et al., 2021). Here, PPARGC1A is linked to metabolic dysfunction-associated steatotic liver disease.