Inactivation of VHL inactivation stabilises HIF1α and HIF2α transcription factors, which activate downstream pathways to regulate iron metabolism [36], angiogenesis (vascular endothelial growth factor and platelet-derived growth factor), glycolysis (pyruvate dehydrogenase kinase 1 [37]), lipid disposition (carnitine palmitoyl transferase 1A [5]), and other processes that drive cancer progression. The gene discussed is EPAS1; the disease is cancer.