The molecular features of RCC are modulated by different genes, including VHL, MET, FLCN, TSC1, TSC2, FH, TFE3, TFEB, MITF, SDH, and PTEN, to alert various aspects of metabolism (Linehan et al., 2010; Linehan and Ricketts, 2013). Here, TSC2 is linked to renal cell carcinoma.