The molecular features of RCC are modulated by different genes, including VHL, MET, FLCN, TSC1, TSC2, FH, TFE3, TFEB, MITF, SDH, and PTEN, to alert various aspects of metabolism (Linehan et al., 2010; Linehan and Ricketts, 2013). This evidence concerns the gene TFE3 and renal cell carcinoma.