RORC and T-cell leukemia: Notably, Subramanian et al. (Subramanian et al., 2019) found that RORC expression decreased with age in human T lymphocytic virus (HTLV)-1-infected patients who did not develop adult T-cell leukemia (which can occur decades after HTLV-1 infection (Nakahata et al., 2011)), demonstrating that an age-dependent decline in RORC expression indicates a possible early event in HTLV-1-driven leukemogenesis.