Recent studies have also shown that CDC45 regulated MCM7 in acute myeloid leukemia through the PI3K/AKT pathway, and another mechanism whereby replication partially disrupted eukaryotic DNA replication and triggered by ubiquitination of replication helicases (Zhang et al., 2021b; Jenkyn-Bedford et al., 2021). Here, CDC45 is linked to acute myeloid leukemia.