FASN and nonpapillary renal cell carcinoma: Mutations in stearoyl-CoA desaturase 1, fatty acid synthase and acetyl-CoA carboxylase in ccRCC can lead to the substantial synthesis of acetyl-CoA, thus causing an abnormal pathway of fatty acid synthesis in ccRCC (Sajnani et al., 2017; Maan et al., 2018).