Finally, the association between CALR, HSP90B1, SRPRB, YIF1A and TRIB3 expression and overall survival in BLCA was analysed using the Cox analysis technique; univariate analysis revealed that HSP90B1 expression (HR = 1.27608, p = 0.0301), TRIB3 expression (HR = 1.20885, p = 0.00137), YIF1A expression (HR = 1.72475, P = 1e-04), CALR expression (HR = 1.46921, p = 0.00217) and SRPRB expression (HR = 1.5969, p = 0.00114) were strongly linked with overall survival (Figures 5D–H). The gene discussed is SRPRB; the disease is bladder transitional cell carcinoma.