PRKCE and neoplasm: The previous study found PKC epsilon (ε) upregulated in KIRC and was associated with tumor grade and T stage in clear cell RCC (ccRCC), but the mechanism of PKC epsilon (ε) increased expression in ccRCC is not fully clarified, interestingly, the protein level of PRKCE was weakly expressed in 786-O, OS-RC-2, SN12C, and SKRC39 cell lines (Huang et al., 2011).