KEGG pathway functional annotations indicated that PRKCE was involved in the chemokine signaling pathway (p = 1.37e-11), T cell receptor signaling pathway (p = 1.52e-11), and PD-L1 expression and PD-1 checkpoint pathway in cancer (p = 6.37e-08) (Supplementary Table S4). The gene discussed is PDCD1; the disease is cancer.