There was also no correlation between total distance travelled and cognitive or anxiety-like behavior measures in hyperactive APP/PS1 mice (Y-maze: distance & time spent: p = 0.5093, r = 0.2372; distance & entering number: p = 0.7652, r = 0.1086; EPM: distance & time spent: p = 0.5750, r = 0.2024; distance & entering number: p = 0.7881, r = 0.09781, n = 10, Pearson correlation analysis; Supplementary Fig. 1A, B). The gene discussed is APP; the disease is Anxiety.