ERCC1-deficient mice have pathological manifestations similar to PD, including reduced striatal dopaminergic innervation, higher levels of phosphorylated synuclein, and impaired mitochondrial respiration, and are more susceptible to the PD toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) [33]. Here, SNCA is linked to Parkinson disease.