Mechanistically, miR-124 deficiency in the brain led to upregulation of the Ryanodine receptor 3 (RyR3, an intracellular calcium-release channel) and the cognitive deficits in miR-124-3 knockout mice were ameliorated by knocking down RyR3 expression using RNAi. The gene discussed is RYR3; the disease is Cognitive impairment.