The top ten significantly enriched KEGG pathways were Pathways in cancer (hsa05200), AGE-RAGE signaling pathway in diabetic complications (hsa04933), MAPK signaling pathway (hsa04010), Insulin resistance (hsa04931), Platelet activation (hsa04611), Measles (hsa05162), NF-kappa B signaling pathway (hsa04064), Rheumatoid arthritis (hsa05323), Inflammatory bowel disease (IBD) (hsa05321) and Transcriptional misregulation in cancer (hsa05202). This evidence concerns the gene INS and rheumatoid arthritis.