Based on microarray data and TCGA database analysis, we identified miR-10b-5p and miR-150-5p target mRNA pairs, which included TOMM70A, RBM48, BEND3, RHOBTB1 and ADAMTS2. The five mRNAs were markedly upregulated in CRC patients compared with healthy donors from TCGA database. Here, TOMM70 is linked to colorectal carcinoma.