This study highlighted a novel ceRNA mechanism in which exosomal lncRNA G016261 and lncRNA XLOC_011677-sponging miR-10b-5p and miR-150-5p regulate the expression of RBM48 and BEND3. A diagnostic model based on miRNAs in the ceRNA network might help in improving the diagnosis efficiency for CRC patients compared to miRNAs alone. This evidence concerns the gene RBM48 and colorectal carcinoma.