This study highlighted a novel ceRNA mechanism in which exosomal lncRNA G016261 and lncRNA XLOC_011677-sponging miR-10b-5p and miR-150-5p regulate the expression of RBM48 and BEND3. A diagnostic model based on miRNAs in the ceRNA network might help in improving the diagnosis efficiency for CRC patients compared to miRNAs alone. Here, BEND3 is linked to colorectal carcinoma.