H. pylori seroprevalence was 82% in 121 cases of PC, whereas the rate was 73% in the control group with 226 subjects. The findings of this study suggested a possible role of H. pylori infection in the development of pancreatic cancer; OR (95% CI), for H. pylori = 1.87 (1.05-3.34); OR (95% CI), for CagA+ = 2.01 (1.09-3.70). Here, S100A8 is linked to familial pancreatic carcinoma.