We used Tyk2Δ/Δ mice with a Tyk2 germline deletion, Tyk2ΔIEC mice (Tyk2fl/fl Villin-cre) with specific deletion of Tyk2 in the intestinal epithelium and Tyk2ΔHem mice (Tyk2fl/fl Vav-cre) with specific deletion of Tyk2 in hematopoietic cells to study cancer cell-intrinsic and extrinsic functions of Tyk2 in CRC. This evidence concerns the gene TYK2 and cancer.