IDO1 and cancer: The presence of Ido1-expressing Paneth-like cancer cells was associated with increased tumor burden and reduced T-cell infiltration in tumors of ApcMin mice, while no correlation with tumor cell proliferation or apoptosis was observed.28 We expected a similar phenotype in Tyk2ΔIEC tumors and characterized tumor parameters, Stat expression, and immune cell infiltration by IHC and FACS analyses.