TYK2 and neoplasm: While the importance of Tyk2 in cancer immune surveillance is well established, there is little evidence of Tyk2 functions in cancer cells.46 Tyk2 has been shown to drive human cancer cell invasion and metastasis in a cancer cell-intrinsic manner.14 The AOM-DSS model does not allow assessment of metastasis, but comparison of tumor data in Tyk2Δ/Δ and Tyk2ΔIEC mice rather suggest an anti-metastatic function of Tyk2 in cancer cells, which becomes evident when Tyk2-mediated immune surveillance is impaired.