In this study, we found that subjects with minor allele genotypes (GA, GG) of the SCARB1 gene were associated with an increased risk of T2DM, which demonstrated that, for healthy carriers of this gene, regularly monitor of circulating lipids (especially the HDL-C level) and blood glucose levels might be benefit to reduce the risk of T2DM. This evidence concerns the gene SCARB1 and type 2 diabetes mellitus.