FTO and obesity due to melanocortin 4 receptor deficiency: Of note, the fat mass and obesity-associated (FTO) gene is one of the most known genetic factors predisposing humans to non-monogenic obesity, and the FTO SNP variant has the strongest known effect on increased BMI and body fat (8, 9), which could be the potential risk factor for disturbing lipid metabolism and increasing the risk of CVD (10).