TF and fibrosis: For other liver diseases, after updating case number and sample size from Gene ATLAS (Figure 6), genetically determined higher systemic iron status (represented by all four biomarkers) became significantly associated with increased fibrosis and cirrhosis risk, odds ratios per SD increase in biomarker levels were 1.53 (95% CI 1.11–2.11, P = 0.010) for serum iron, 1.55 (95% CI 1.23–1.95, P = 2.1 × 10−4) for transferrin saturation, 4.44 (95% CI 2.19–8.99, P = 3.4 × 10−5) for ferritin, and 0.42 (95% CI 0.30–0.59, P = 4.5 × 10−7) for serum transferrin.