In this work, we have extracted the largest available and updated datasets from UK Biobank to interrogate the potential effect of iron status (referred to serum iron, ferritin, transferrin, and transferrin saturation in a pattern consistent with an effect on systemic iron status), on liver function, proxied by multiple biomarkers (ALT, AST, ALP, GGT, DBIL, and TBIL), as well as on related liver diseases (including nonalcoholic fatty liver disease (NAFLD), alcoholic liver disease (ALD), viral hepatitis, liver fibrosis and/or cirrhosis and liver malignant neoplasm). This evidence concerns the gene TF and Cirrhosis.