MDM2 and glioblastoma: Genetic aberration associated with TP53/MDM2/p14ARF pathway accounts for 87% of cases of glioblastoma, over expression of MDM2 induces GBM in 14% patients, 49% GBM roots out from p14ARF homozygous deletion, and Tp53 mutation results in 35% of glioblastoma cases [56].