CASP3 and neoplasm: In addition, the results of western blotting revealed that upon treatment with low-dose EO, high-dose EO, or adriamycin, caspase-3 protein expression was increased while the Ki-67 protein expression was suppressed in the TNBC-tumor bearing mice (whether the mice were injected with MDA-MB-231 or MDA-MB-453 cells) compared with the mice in the blank control group (p < 0.05, Figure 8(b)).