AKT1 and neoplasm: Likewise, whether the mice were injected with MDA-MB-231 or MDA-MB-453 cells, by western blotting, we observed Akt phosphorylation was significantly downregulated while p38 phosphorylation was obviously upregulated upon treatment with low-dose EO, high-dose EO, or adriamycin in the TNBC-tumor bearing mice (p < 0.05).