Targeting p53-MDM2/MDMX interactions, a series of stapled peptides originating from different stapling chemistries have been designed, of which the notable example ALRN-6924, a hydrocarbon stapled MDM2/MDMX antagonist, can reactivate the p53 pathway, and this drug candidate has entered phase II clinical trials for advanced solid tumors and lymphomas 17. This evidence concerns the gene MDM2 and lymphoma.