Based on the previously developed anti-Aβ42 mAb 1F12, we demonstrate that HA-MMSN-1F12, obtained by modifying the MMSN surface with HA and 1F12, reduces brain Aβ burden and neuroinflammation, and improves cognitive deficits in APP/PS1 mice. The gene discussed is APP; the disease is Cognitive impairment.