iMon subset is functionally linked with neo-vascularization in the advanced AS plaques by producing inflammatory cytokines, i.e., IL-1β, IL-6, and TNF-α 69, and previous studies also have confirmed the important roles of serum LDL and TC-rich lipoproteins in driving human atherosclerosis 70, 71. The gene discussed is IL1B; the disease is atherosclerosis.