KCNJ8 and depressive symptom measurement: We then used astrocyte-specific knockout of Kir6.1 mice to prepare two well-known mouse models of depression (CUMS and CSDS) and found that Kir6.1 CKO mice exhibited more severe depressive-like behavior including the lower social interaction ratio and sucrose preference and the longer the duration of immobility in FST and TST.