Results showed that knockdown of MCM6 evidently suppressed the peritoneal dissemination as exemplified by fewer tumor nodules on the peritoneal surfaces in shMCM6 groups as compared with the control group, in agreement with the MCM6-induced epithelial-to-mesenchymal transition (EMT) phenomenon (Figure 5E and Figure 3K-M). Here, MCM6 is linked to neoplasm.