With the exception of TROP2, all proven or putative markers of SCs (ALDH1A1, NANOG, SOX2, OCT4, KLF4, EGR1, BMI1, LGR5, LGR6, LRIG1, TSPAN7, and TSPAN13) were expressed in LNs from control patients to similar or even higher levels than in PC patients (Fig. 2). This evidence concerns the gene LRIG1 and pachyonychia congenita.