Alpl knockout (Alpl−/−) mice phenocopy infantile HPP extremely well, including their failure to thrive, high-pitched cries, rickets and extensive hypomineralization of their skeleton, and severe seizures that precede death within a few weeks after birth (though a pyridoxal-enforced diet can reduce seizures and slightly extend lifespan) (20–22). This evidence concerns the gene ALPL and hypophosphatasia.