Currently known, pathways that OP and AD may share include RANK-RANKL (Luckhaus et al., 2009; Stapledon et al., 2021), vitamin D receptor (Morello et al., 2018; Jia et al., 2019), C/EBPβ-δ-secretase (Xiong et al., 2022), PI3K-Akt (Fehsel and Christl, 2022), and Wnt/β-catenin (Li et al., 2013; Dengler-Crish et al., 2018; Folke et al., 2019), among which Wnt/β-catenin had the most attention. The gene discussed is TNFSF11; the disease is Alzheimer disease.