GSK3B and atrial fibrillation: In mouse and cellular models, AF (amentoflavone) downregulated NLRP3 and other pyroptosis-related protein levels through activation of AMP-activated protein kinase (AMPK)/Glycogen synthase kinase-3beta (GSK3β) signaling pathway, ultimately inhibiting Aβ1-42-induced hippocampal neuronal pyroptosis (Zhao et al., 2019).