MAPT and Alzheimer disease: In the current study, aggregated Aβ and tau activation of NLRP3 (NOD-like receptor protein 3) inflammasome-mediated neuroinflammatory responses and neuronal pyroptosis were found in AD patients and animal models, whereas inhibition of this set of responses attenuated the progression of AD (Meda et al., 1995; Tan et al., 2014; Han et al., 2020b; Perea et al., 2020).