In the Amyloid precursor protein (APP)/presenilin-1 (PS1) mouse model, U50488H (κ-opioid receptor agonist) ameliorated synaptic plasticity and AD-related symptoms by inhibiting NLRP3-induced hippocampal microglia pyroptosis (Song et al., 2021). The gene discussed is PSEN1; the disease is Alzheimer disease.