A confirmative cohort meta-analysis showed a linear association between CRP level and stroke (P = 0.940), as well as with CVD (P = 0.429), and CHD (P = 0.931); for each 1-mg/L increase in CRP level, the pooled RRs for stroke, CVD and CHD were 1.07, 1.18, and 1.12, respectively (Yang et al., 2021). This evidence concerns the gene CRP and Stroke.