MAPT and type 2 diabetes mellitus: Furthermore, gene-based analyses suggested that T2DM-related genes were mainly enriched in the cortical neurons and might modulate ion and protein binding, neural development and generation, cell junction and projection, PI3K-Akt, and MAPK signaling pathway, which accelerated the aMCI’s conversion to AD by affecting Tau phosphorylation and Aβ accumulation (Karran et al., 2011).