These enrichment analysis results suggested that these T2DM-related genetic variants are highly expressed in the cortical neurons, modulate ion and protein binding, neural development and generation, cell junction and projection, the PI3K-Akt and MAPK signaling pathway, and further affect Tau phosphorylation (Salkovic-Petrisic et al., 2006; Ke et al., 2009) and Aβ accumulation (Yang et al., 2014), accelerating the conversion of aMCI to AD. This evidence concerns the gene AKT1 and type 2 diabetes mellitus.