Furthermore, gene-based analyses suggested that T2DM-related genes were mainly enriched in the cortical neurons and might modulate ion and protein binding, neural development and generation, cell junction and projection, PI3K-Akt, and MAPK signaling pathway, which accelerated the aMCI’s conversion to AD by affecting Tau phosphorylation and Aβ accumulation (Karran et al., 2011). This evidence concerns the gene AKT1 and Alzheimer disease.