T2DM-related genetic genes are highly expressed in the cortical neurons, may modulate ion and protein binding, neural development and generation, cell junction and projection, and the PI3K-Akt and MAPK signaling pathways, which is related to Tau phosphorylation and Aβ accumulation, accelerating the conversion of aMCI to AD. The gene discussed is AKT1; the disease is type 2 diabetes mellitus.