Packer et al. (2008) have reported the reduction of expression of numerous miRNAs with upstream RE1 sites in cortex samples of HD patients compared with healthy controls. Notably, among these miRNAs has been the bifunctional brain enriched miR-9/miR-9* which targets two constituents of the REST complex (Packer et al., 2008). This evidence concerns the gene REST and Huntington disease.