The results demonstrated that ATG5 expression was significantly positively correlated with tumor proliferation signatures, MYC targets, DNA repair, DNA replication, and G2M checkpoint in HNSCC (p < 0.05, Figures 6A–E), and the Spearman coefficients were 0.38, 0.28, 0.25, 0.34, and 0.41, respectively. The gene discussed is MYC; the disease is head and neck squamous cell carcinoma.