IFNG and cancer: According to the report, during cancer immunotherapy, ferroptosis can be activated by interferon gamma (IFNγ) released from CD8+ T cells, and IFNγ down-regulates the expression of SLC3A2 and SLC7A11 to reduce the uptake of cystine in tumor cells, leading to ferroptosis in tumor cells (Wang, Green et al., 2019).