Xue M. et al. (Xue et al., 2017) found that exosomes derived from bladder cancer cells under a hostile hypoxic microenvironment and carrying lncRNA-UCA1 promoted tumor progression, moreover, its exosomal lncRNA-UCA1 in human serum may provide a potent diagnostic biomarker for bladder cancer. Here, UCA1 is linked to urinary bladder carcinoma.