To verify the role of EGFR-TGF-β1-Smad3 signaling pathway in LF cells-induced collagen I and collagen III expression, EGFR-specific inhibitor erlotinib and TGF-β1 neutralizing antibody were respectively used to treat LF cells exposed with exogenous EGF. The gene discussed is TGFB1; the disease is Lassa fever.