In univariate Cox proportional hazards regression analysis, age, sex, smoking, drinking, physical activity, educational status, history of hypertension, history of diabetes mellitus, history of dyslipidemia, red blood count, serum hemoglobin, albumin, hemoglobin A1c, total cholesterol and uric acid were significantly associated with incident cataract development (Table 2). The gene discussed is ALB; the disease is metabolic syndrome.