(31) have reported that 0.2 μM and 0.4 μM of rapamycin increased the number of apoptotic cells and the cell cycle of retinoblastoma cells was basically stopped in S phase and consequently, the expression levels of Bcl-2, PI3K and AKT declined with rapamycin stimulation at 0.2 μM and 0.4 μM (31). Here, AKT1 is linked to retinoblastoma.