EGFR and non-small cell lung carcinoma: In the context of NSCLC, PD-1 and PD-L1 inhibitors such as pembrolizumab, nivolumab, and atezolizumab in combination with chemotherapy have become the standard-of-care in frontline therapy after demonstrating significant improvements over chemotherapy with regards to ORR, PFS, and OS in patients without EGFR-activating mutations (180).