Both HCC and LC patients when HBsAg(+) presented additional variables significantly disturbed such as aminotransferases, total bilirubin, APRI, or MELD score (Model for End-Stage Liver Disease, that combines albumin and total bilirubin concentrations, Index Normalized Ratio, and presence of ascites and encephalopathy, not shown), this latter variable assessing disease severity. This evidence concerns the gene ALB and laryngotracheoesophageal cleft.