In addition, the use of HDACi was reported to have the immunomodulatory effect on NKG2D system, and was able to reverse the RT-insensitive cancer cells with DNA damage-dependent NKG2D ligands, MICA/MICB-, to MICA/MICB+ cells as well as sensitize these cells for NK cell mediated cytotoxicity (12, 13). This evidence concerns the gene MICA and cancer.