These results encourage to also further investigate the potential anti-BC properties of Calebin A. In fact, a first study (Table 2) showed a dose-dependent inflammation- and thus proliferation-reduction in MCF-7 (BC cells) via suppression of TNF-α-induced NF-κB activation (98) by Calebin A. Furthermore, in another BC cell line, MDA-MB-231 the induction of osteoclastogenesis in mouse macrophage cells (RAW264.7) was observed, supporting the idea of bone loss as major secondary BC disease. This evidence concerns the gene TNF and breast cancer.