Therefore, it is a promising finding, that Calebin A significantly reduced the survival of cisplatin resistant A549 LC cells by modulating P-glycoprotein as well as pro-apoptotic agents p53, Bax and caspase-3 (109), evidencing that Calebin A was able to overcome resistance of these cancer cells in vitro (Table 2). The gene discussed is TP53; the disease is cancer.