Underlining this, histiocytic lymphoma cells (U937) showed increased activation of the inflammatory NF-κB cascade activated by TNF signals (122), representing a signaling pathway that acts as a target of natural polyphenolic agents such as Calebin A. As shown in Table 2, Calebin A inhibited NF-κB-promoted inflammation by intervening in the pathological TNF-α/NF-κB activation in U937 lymphoma cells (98). The gene discussed is NFKB1; the disease is reticulum cell sarcoma.