Members of the histone methyltransferases family, such as lysine methyltransferase 2 (KMT2) are also involved in the growth and spread of breast cancer cells, where they mediate the active histone methylation of H3K4 at the enhancer and the promoter regions of oncogenes and pro-metastatic genes, thereby facilitating the activation of genes that are estrogen dependent (120–123). Here, PRDM9 is linked to breast cancer.