CXXC1 and Familial prostate cancer: Finally, expression of proteins associated with epigenetics (Table S11, Figure 8G) was also modified as Histone H1.5, a regulator of individual gene transcription and overexpression in prostate cancer, increased about 12-fold, while the expression of CXXC-type zinc finger protein 1, a transcriptional activator was reduced by 135-fold in SMAC-KO cells.