The expression of proteins related to DNA and RNA (Table S9) also was modified in SMAC-KO cells as schlafen family member 11 (SLFN11), an inhibitor of DNA replication, was increased about 14-fold, while the expression levels of protein bicaudal C homolog 1, an ARNA binding protein that acts as a negative regulator of Wnt signaling and is upregulated in oral cancer tissues, was decreased over 2-fold. Here, DIABLO is linked to lip and oral cavity carcinoma.