THRB and renal cell carcinoma: Only 194 unique TRB-CDR3s (0.05%) from the 14 TIL repertoires matched CDR3s from TCRs that have previously been associated with T-cell responses to one of the 13 defined pathogens or public tumor-antigen targets (non-RCC), with individual clonal expansion no greater than 1.3% of the corresponding sample repertoire (Supplementary Figure 1B).