BRD2 and neoplasm: By comparing the TCR repertoire present in ccRCC tumor with autologous NAT and PBMC using two complementary scRNAseq approaches, we identified two dominant phenotypes in the expanded clones in the ccRCC microenvironment: 1) T-cell clonotypes defined by their TRB-CDR3 sequences that were found only in tumor, and 2) T-cell clonotypes shared by tumor with PBMC and/or NAT.