Five of eight CAIX+ tumors had increased CD4+ and CD8+ T-cell infiltration into the CAIX+ areas (Figures 1D, E top panels), whereas in three tumors, the opposite pattern was observed, with CD4+ and CD8+ T cells being mostly excluded from the CAIX+ tumor regions (Figures 1D, E bottom panels). The gene discussed is CD8A; the disease is neoplasm.