Significant differences were observed in terms of age, gender, smoking history, TNM stage, Ki-67 expression, lymph node or pleural metastasis, and STAS between the HGP group and the n-HGP group (p = 0.020, p = 0.025, p = 0.027, p < 0.001, p < 0.001, p < 0.001, p < 0.001), yet no remarkable difference could be detected in tumor location and EGFR expression (p = 0.360, p = 0.586). The gene discussed is EGFR; the disease is neoplasm.