The deletion of NCOA4 can inhibit the reduction in the level of the FTH1 protein caused by cystine deprivation, and cystine deprivation simultaneously induces the accumulation of light chain 3 (LC3)-II protein associated with microtubules, enhances ferritin phagocytosis, and then promotes ferroptosis in GBM cells (90). The gene discussed is NCOA4; the disease is glioblastoma.