Similar to the previous monoamines, the role of some proinflammatory cytokines like TNF-α and IL-1 due to cancer or after cancer therapy appears to increase 5-HT and norepinephrine reuptake transporters, through activation of the p38 mitogen-activated protein kinase (MAPK), driving the onset of depressive symptoms (5). The gene discussed is TNF; the disease is cancer.