CD4 and myocarditis: For example, ICI-associated myocarditis biomarkers may detect between the different phenotypes of myocarditis; lymphocytic myocarditis is facilitated by proinflammatory TH17 cells and CCR5, and giant cell myocarditis is thought to originate from the autoantigen-triggered immunoproteasome, leading to CD4+ T cell recruitment and differentiation into TH1 and TH17 cells (64).