Tumor cells express ligands for immune checkpoint proteins such as the cytotoxic T lymphocyte-associated protein 4 (CTLA-4 also known as CD152), the programmed cell death 1 (PD-1 also known as CD278), and Lymphocyte Activation Gene-3 (LAG-3 also known as CD223) receptor molecules expressed on T lymphocytes. This evidence concerns the gene CTLA4 and neoplasm.