Multivariate analyses indicated that only sIL-8 was an independent risk factor for tumor recurrence in the intestinal-type tumor, that no independent risk factor was observed in the diffuse-type tumor, and that sIL-8 (P = 0.004) and CEA (P < 0.001) were independent risk factors for tumor relapse in the mixed-type tumor (Table 6). The gene discussed is CEACAM5; the disease is neoplasm.